In clinical settings, providers are forced to grapple with the challenge of advising misinformed patients. Yet, addressing harmful misinformation during visits has been largely left out of medical education and training. Very little is known about how to do so. The Misinfo Rx Toolkit was created to help address this gap and counter the impacts of medical misinformation. Grounded in recent research on mis- and disinformation, the Misinfo Rx Toolkit provides strategies for addressing patient-held misinformation in clinical settings. Following the “Three C” approach, providers are encouraged to practice empathy, employ curiosity, and acknowledge resource constraints through compassionate conversations oriented towards patient-provider relationships that are built on trust.